Reflection: ELL Students Super Genomics to the Rescue: Explaining and Treating Neurological Based Ailments! - Section 4: Explain


         In this class, it is a basic expectation that students will come into a lesson like this with a descent command of enzyme structure and function. Yet and still, it proved challenging for some of my students to visualize SPR as an enzyme and tetrahydropterin as a substrate when exploring the SPR/Nt biochemical . To make this interaction more visible and jump out of the metabolic map, I provided students with copies of my Enzyme in Action Modeling Kits and briefly guided them through a modeling activity which allowed for students to physically manipulate the kits pieces to avail the following:

a) Labeling the critical enzyme and substrate components in normal SPR functions.

b) Modeling standard interactions between SPR and its substrate.

c) Modeling interactions between SPR's substrate and a mutated form of SPR.

At the various modeling points, students were encourage to take photos of the models to remind them of the major physical interaction that occurs between SPR (the key to DRD) and its substrate. 

(See student modeling photos attached)

  ELL Students: Revisiting and Applying Enzyme Mechanics to DRD!
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Super Genomics to the Rescue: Explaining and Treating Neurological Based Ailments!

Unit 7: Genetics and the Brain
Lesson 6 of 6

Objective: Students will analyze models of altered proteins and scripts from a genetic code to construct an explanation for the basis and treatment of a rare neurological disorder.

Big Idea: The Human Genome Project provides us access to individual genetic defects, which allows for us to better understand the molecular protein products which serve as the crux of neurological diseases.

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